Rational Design of Natural Xanthones Against Gram‐negative Bacteria (Adv. Sci. 14/2025)
Gram-neGative BacteriaMost antibiotics are ineffective against Gram-negative bacteria due to the presence of the outer membrane (OM).In article number 2411923, Jianzhong Shen, Kui Zhu, and co-workers screened natural xanthone skeletons with the potential to penetrate the OM after amine modification.These optimized compounds cross the OM via a self-promoted pathway, facilitating the discovery of novel antibacterial agents.
Authors
- Meirong Song (ORCID: https://orcid.org/0009-0007-4238-5112)
- Shuyu Yang (ORCID: https://orcid.org/0000-0002-0537-7515)
- Kui Zhu (ORCID: https://orcid.org/0000-0001-8242-3952)
- Jijun Kang
- Ying Liu (ORCID: https://orcid.org/0000-0002-4631-0915)
- Shang Chen (ORCID: https://orcid.org/0000-0001-9307-5666)
- Xiaojia Liu (ORCID: https://orcid.org/0000-0002-7375-8993)
- Jianzhong Shen (ORCID: https://orcid.org/0000-0002-0128-1874)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/advs.202570099
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00