Improved Efficacy of Triple‐Negative Breast Cancer Immunotherapy via Hydrogel‐Based Co‐Delivery of CAR‐T Cells and Mitophagy Agonist (Adv. Sci. 14/2025)

CAR‐T‐Cell Therapy In article number 2409835 by , Beichen Liu, Yuan Gao, Huadong Zhao, and co‐workers, injection hydrogels are engineered for the controlled co‐delivery of CAR‐T cells and BC1618 that improves the treatment of TNBC. On the cover: The ocean currents represent the delivery medium of CAR‐T cells, which is the hydrogel. The schools of small fish swimming around symbolize BC1618, an agonist that can enhance the function of CAR‐T cells. The shark represents tumor cells, while the narwhal represents CAR‐T cells with enhanced attack power after being delivered by the hydrogel. The dolphins in the background represent regular CAR‐T cells, which have relatively weaker attack power. [Image: see text]