[<sup>18</sup>F]Radiolabeling fluorination of monofluoroalkyl triflates for the synthesis of [<sup>18</sup>F]difluoromethylated alkanes
An efficient method for the synthesis of [<sup>18</sup>F]-difluoromethylated alkanes by the combination of [<sup>18</sup>F]radio-fluoride with monofluoroalkyl triflates has been developed. This method uses [<sup>18</sup>F]KF/K<sub>2.2.2</sub> as the fluorine source. It features synthetic simplicity without tedious precursor preparation, high RCC and RCY, good functional group tolerance, and is silver salt-free, providing potential for developing new PET agents.
Authors
- Xingang Zhang (ORCID: https://orcid.org/0000-0002-4406-6533)
- Junbin Han (ORCID: https://orcid.org/0000-0002-2781-7710)
- Ying Han (ORCID: https://orcid.org/0000-0002-2424-5163)
- Pengfei Song (ORCID: https://orcid.org/0000-0003-2315-7572)
- Haiyang Zhao (ORCID: https://orcid.org/0009-0004-2682-2747)
Institutions
- Fudan University (CN)
- Zhengzhou University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00869g
- Citations
- 3
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.37