<i>BRCA1/2</i> and Other Predisposition Genes in High-Risk Hormone Receptor+/Human Epidermal Growth Factor Receptor 2– Breast Cancer Treated With Endocrine Therapy With or Without Palbociclib: A Secondary PENELOPE-B Study Analysis
Patients with <i>BRCA1/2</i> PVs had numerically better outcomes after palbociclib. However, the number of <i>BRCA1/2</i> carriers was small. Larger randomized clinical trials should consider the PV status to further evaluate whether <i>BRCA1/2</i> PV carriers benefit from cyclin-dependent kinase 4 and 6 inhibitor treatment.
Authors
- Michael Untch (ORCID: https://orcid.org/0000-0002-1233-1267)
- Angela M. DeMichele (ORCID: https://orcid.org/0000-0003-1297-4251)
- Nicole McCarthy (ORCID: https://orcid.org/0000-0001-7394-8909)
- Frederik Marmé (ORCID: https://orcid.org/0000-0002-6591-3367)
- Federico Rojo (ORCID: https://orcid.org/0000-0001-9989-0290)
- Laura van ‘t Veer (ORCID: https://orcid.org/0000-0002-9838-8298)
- Peter A. Fasching (ORCID: https://orcid.org/0000-0003-4885-8471)
- Michael Gnant (ORCID: https://orcid.org/0000-0003-1002-2118)
- Sung‐Bae Kim (ORCID: https://orcid.org/0000-0001-5588-8332)
- Erik S. Knudsen (ORCID: https://orcid.org/0000-0002-5130-5969)
- Martin Filipits (ORCID: https://orcid.org/0000-0003-2847-4534)
- Christian Schem (ORCID: https://orcid.org/0000-0001-8606-3077)
- Carsten Denkert (ORCID: https://orcid.org/0000-0002-2249-0982)
- Agnieszka Katarzyna Witkiewicz (ORCID: https://orcid.org/0000-0003-4538-1145)
- Andreas Makris (ORCID: https://orcid.org/0000-0002-2003-1088)
- Kerstin Becker (ORCID: https://orcid.org/0009-0009-7897-7181)
- Olga Valota (ORCID: https://orcid.org/0000-0002-7583-9914)
- Karsten E. Weber (ORCID: https://orcid.org/0000-0003-0001-2135)
- Toralf Reimer (ORCID: https://orcid.org/0000-0003-3014-370X)
- Hervé Bonnefoi (ORCID: https://orcid.org/0000-0003-4293-9748)
- Valentina Nekljudova (ORCID: https://orcid.org/0000-0002-2801-7387)
- Nicholas C. Turner (ORCID: https://orcid.org/0000-0001-8937-0873)
- Harry D. Bear (ORCID: https://orcid.org/0000-0002-7632-9019)
- Karen A. Gelmon (ORCID: https://orcid.org/0000-0003-4111-2757)
- Seock‐Ah Im (ORCID: https://orcid.org/0000-0002-5396-6533)
- Jan Hauke (ORCID: https://orcid.org/0000-0001-8236-4075)
- Eric Hahnen (ORCID: https://orcid.org/0000-0002-1152-8367)
- Catherine M. Kelly (ORCID: https://orcid.org/0000-0001-8355-6714)
- Bärbel Felder (ORCID: https://orcid.org/0009-0001-0072-0097)
- Corinna Ernst (ORCID: https://orcid.org/0000-0001-7756-8815)
- Sibylle Loibl (ORCID: https://orcid.org/0000-0001-6488-4958)
- Hope S. Rugo (ORCID: https://orcid.org/0000-0001-6710-4814)
- Lesley‐Ann Martin (ORCID: https://orcid.org/0000-0002-7606-4161)
- Masakazu Toi (ORCID: https://orcid.org/0000-0003-1488-9958)
- Yuan Liu (ORCID: https://orcid.org/0000-0003-2668-0350)
- Miguel Martín (ORCID: https://orcid.org/0000-0001-9237-3231)
- Kerstin Rhiem (ORCID: https://orcid.org/0000-0002-9669-5657)
- José A. García-Sáenz
Institutions
- Ulsan College (KR)
- Roswell Park Comprehensive Cancer Center (US)
- Institute of Cancer Research (GB)
- Université de Bordeaux (FR)
- Inserm (FR)
- Philipps University of Marburg (DE)
- The University of Queensland (AU)
- University of California, San Francisco (US)
- University of Cologne (DE)
- Virginia Commonwealth University (US)
- Kyoto University (JP)
- Breast Cancer Now (GB)
- Asan Medical Center (KR)
- Seoul National University Hospital (KR)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- University of Ulsan (KR)
- Universitätsklinikum Erlangen (DE)
- Institute of Cancer Research (CA)
- Comprehensive Cancer Center Vienna (AT)
- Cancer Trials Australia (AU)
- University of Miami Health System (US)
- Mount Vernon Cancer Centre (GB)
- Frauenklinik Heidelberg (DE)
- Mammazentrum Hamburg (DE)
- Penn Center for AIDS Research (US)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- German Breast group (DE)
- Institut Bergonié (FR)
- Helios Kliniken (DE)
- Pfizer (Italy) (IT)
- University of Pennsylvania Health System (US)
- University Hospital Cologne (DE)
- St. James's Hospital (IE)
- Helios Hospital Berlin-Buch (DE)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Abramson Cancer Center (US)
- University of Rostock (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1200/po-24-00742
- Citations
- 2
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 3.04