Methods of correction of virus-induced inhibition of endogenous interferon type I synthesis

Numerous studies conducted in our country and abroad have established that many viruses in the process of evolutionary phylogenesis have acquired effective molecular-biological mechanisms for suppressing the synthesis of endogenous interferon. The review reveals complex molecular-biological mechanisms of viruses bypassing antiviral interferon immunity, detailing various types of interferon inhibition in the most epidemiologically significant viruses – influenza, coronaviruses, including SARS-CoV-2, enteroviruses, herpesviruses, rotavirus, adenovirus, measles virus, HIV, hepatitis B virus, Zika virus, and others. Lack of sufficient and timely production of interferon leads to impaired realization of further immune mechanisms, which is sufficient justification for active replacement of the missing volumes by a ready-made interferon preparation to effectively combat viral aggression. The preparation of recombinant interferon-alpha-2b (VIFERON®), which contains a complex of highly active membrane-stabilizing antioxidants with synergistic action, can be recommended as the drug of choice. Key words: virus, interferon, synthesis inhibition, regulatory proteins, influenza, acute respiratory infections, COVID-19, mixed infection, antioxidants