Tetracyclines at subinhibitory concentrations are lethal for NADH peroxidase–deficient mutants of <i>Enterococcus faecium</i>
This study might pave the way to develop strategies aimed at potentiating tigecycline action by increasing endogenous H2O2 production and/or impairing H2O2 detoxification, potentially improving treatment efficiencies for VR-Efm infections with this last-line antibiotic.
Authors
- Valentin Wasselin (ORCID: https://orcid.org/0000-0002-9832-522X)
- Isabelle Rincé
- Eliette Riboulet-Bisson (ORCID: https://orcid.org/0000-0003-1205-2468)
- Axel Hartke (ORCID: https://orcid.org/0000-0002-2537-0062)
- Aurélie Budin‐Verneuil (ORCID: https://orcid.org/0000-0002-1173-251X)
- Florie Desriac (ORCID: https://orcid.org/0000-0002-6436-6437)
- Abdellah Benachour (ORCID: https://orcid.org/0000-0001-9349-6807)
- Amine M. Boukerb (ORCID: https://orcid.org/0000-0002-8349-6739)
- Julie Plouhinec
Institutions
- Normandie Université (FR)
- Université de Rouen Normandie (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1093/jac/dkaf105
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00