Association of Genetic Variations in The PIK3-AKT-mTOR Pathway with Endometriosis Susceptibility: A Preliminary Case-Control Study.
The results show that <i>PIK3CA</i> rs2230461 and <i>AKT1</i> rs1130233 SNPs are risk factors for endometriosis and the <i>mTOR</i> rs2295080 gene polymorphism is a protective factor for the development of endometriosis in an Iranian cohort. The <i>PIK3CA</i> rs2230461, <i>AKT1</i> rs1130233, and <i>mTOR</i> rs2295080 gene polymorphisms should be further investigated as potential candidate SNPs for predicting endometriosis susceptibility.
Authors
- Mohsen Taheri (ORCID: https://orcid.org/0000-0002-1110-4417)
- Forough Forghani (ORCID: https://orcid.org/0000-0001-7338-3522)
- Danial Jahantigh (ORCID: https://orcid.org/0000-0002-0205-7399)
- Mahnaz Rezaei (ORCID: https://orcid.org/0000-0003-0982-0657)
- Saeedeh Ghazaey Zidanloo (ORCID: https://orcid.org/0000-0003-4441-6086)
- Rahele Ghasemian Moghadam
Institutions
- Kosar University of Bojnord (IR)
- Zahedan University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-11
- DOI
- https://doi.org/10.22074/ijfs.2024.2015384.1567
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zahedan University of Medical Sciences