H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition

The HRR deficiency in H3K27M DMG can be therapeutically leveraged with PARP inhibitors to radiosensitize and induce an NK cell-mediated antitumor immune response selectively in H3K27M DMG, supporting the clinical investigation of PARP1 inhibitors with RT in DMG patients.

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Publication Details

Journal
Neuro-Oncology
Published
2025-04-03
DOI
https://doi.org/10.1093/neuonc/noaf097
Citations
4
Primary Topic
PARP inhibition in cancer therapy
Type
article
Field-Weighted Citation Impact
4.18
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article

H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition

Carl Koschmann, Joshua D. Parsels, Qiang Zhang, Erik Peterson et al.
4 citations
Neuro-Oncology
PARP inhibition in cancer therapy
4.18
article

H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition

Carl Koschmann, Joshua D. Parsels, Qiang Zhang, Erik Peterson, Michael D. Green, Robert Doherty, Meredith A. Morgan, Sujatha Venkataraman, Zhuwen Wang, Theodore S. Lawrence, Daniel Wahl, Zi‐An Li, Sameer Agnihotri, Leslie A. Parsels, Stephanie The, Victoria M. Valvo, Xinjun Wang, Nan Hu, Yupei Guo, Anushka Dalvi, Sriram Venneti
article en
4 citations

Abstract

The HRR deficiency in H3K27M DMG can be therapeutically leveraged with PARP inhibitors to radiosensitize and induce an NK cell-mediated antitumor immune response selectively in H3K27M DMG, supporting the clinical investigation of PARP1 inhibitors with RT in DMG patients.

Neuro-OncologyVol. 27(8)
University of Pittsburgh (US), University of Michigan (US), Fifth Affiliated Hospital of Zhengzhou University (CN), Michigan Medicine (US), Michigan Center for Translational Pathology (US), Michigan Cancer Research Consortium (US), Third Affiliated Hospital of Zhengzhou University (CN), Henan University of Economic and Law (CN), University of Colorado Denver (US)
Good health and well-being
Openalex Percentile: Top 6%
PARP inhibition in cancer therapy
4.18
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