H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition
The HRR deficiency in H3K27M DMG can be therapeutically leveraged with PARP inhibitors to radiosensitize and induce an NK cell-mediated antitumor immune response selectively in H3K27M DMG, supporting the clinical investigation of PARP1 inhibitors with RT in DMG patients.
Authors
- Carl Koschmann (ORCID: https://orcid.org/0000-0002-0825-7615)
- Joshua D. Parsels
- Qiang Zhang (ORCID: https://orcid.org/0009-0006-2175-2289)
- Erik Peterson (ORCID: https://orcid.org/0000-0002-6579-2948)
- Michael D. Green (ORCID: https://orcid.org/0000-0003-4951-7118)
- Robert Doherty (ORCID: https://orcid.org/0000-0001-9307-7995)
- Meredith A. Morgan (ORCID: https://orcid.org/0000-0001-7965-6878)
- Sujatha Venkataraman (ORCID: https://orcid.org/0000-0002-1512-284X)
- Zhuwen Wang (ORCID: https://orcid.org/0009-0008-1203-5979)
- Theodore S. Lawrence (ORCID: https://orcid.org/0000-0002-4186-8821)
- Daniel Wahl (ORCID: https://orcid.org/0000-0001-9894-5085)
- Zi‐An Li (ORCID: https://orcid.org/0000-0002-6338-8933)
- Sameer Agnihotri (ORCID: https://orcid.org/0000-0001-6584-3795)
- Leslie A. Parsels (ORCID: https://orcid.org/0000-0002-5880-1033)
- Stephanie The (ORCID: https://orcid.org/0000-0002-6660-4136)
- Victoria M. Valvo (ORCID: https://orcid.org/0009-0004-5837-4141)
- Xinjun Wang (ORCID: https://orcid.org/0009-0009-9298-031X)
- Nan Hu (ORCID: https://orcid.org/0000-0003-1443-2130)
- Yupei Guo
- Anushka Dalvi
- Sriram Venneti
Institutions
- University of Pittsburgh (US)
- University of Michigan (US)
- Fifth Affiliated Hospital of Zhengzhou University (CN)
- Michigan Medicine (US)
- Michigan Center for Translational Pathology (US)
- Michigan Cancer Research Consortium (US)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Henan University of Economic and Law (CN)
- University of Colorado Denver (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1093/neuonc/noaf097
- Citations
- 4
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.18