Convalescent plasma for the treatment of patients with COVID-19: the Singapore experience and lessons learnt
This study provides a comprehensive overview of the intricacies of Singapore's CP programme, from its operational challenges to the observed clinical outcomes, while highlighting the potential benefits and complexities of CP as a therapeutic option. Successful implementation of the CP programme requires robust collaboration across multidisciplinary teams. Access to serological tests was crucial for donor selection. Both the selection of CP with high neutralising antibodies and careful selection of appropriate recipients are key aspects to optimise the therapeutic success of CP. A meticulous approach is warranted if CP were to be used in future pandemics.
Authors
- Andrew Ang (ORCID: https://orcid.org/0009-0006-9627-7347)
- Suma Rao
- Kiat Hoe Ong (ORCID: https://orcid.org/0009-0005-7646-3591)
- Chee Wah Tan (ORCID: https://orcid.org/0000-0001-9837-1413)
- Barnaby Edward Young (ORCID: https://orcid.org/0000-0003-1010-2230)
- Jun Yang Tay (ORCID: https://orcid.org/0000-0003-1150-8814)
- Wah Wah Naw
- Allison Tso (ORCID: https://orcid.org/0000-0003-3943-7229)
- Shawn Vasoo (ORCID: https://orcid.org/0000-0001-7812-9881)
- Bingwen Eugene Fan (ORCID: https://orcid.org/0000-0003-4367-5182)
- Yee‐Sin Leo (ORCID: https://orcid.org/0000-0003-4978-5825)
- Connie Siew Ping Chen
- David Chien Lye (ORCID: https://orcid.org/0000-0003-0324-0205)
- Ponnudurai Kuperan
- Sing Zern Fong
- Ying Ding (ORCID: https://orcid.org/0000-0003-2567-2009)
- Ai Leen Ang (ORCID: https://orcid.org/0000-0002-7341-6862)
- Lin‐Fa Wang (ORCID: https://orcid.org/0000-0003-2752-0535)
- Venkata Sreekanth Sampath
- Mucheli Sharavan Sadasiv (ORCID: https://orcid.org/0000-0002-5535-5306)
- Christopher Dheepa
- Stephrene Seok Wei Chan (ORCID: https://orcid.org/0000-0003-4828-6303)
- Poh Lian Lim (ORCID: https://orcid.org/0000-0001-6314-6072)
- Wanni Chia
- Laurence Sandig
- Chek Kia Boo
Institutions
- National University of Singapore (SG)
- Health Sciences Authority (SG)
- Tan Tock Seng Hospital (SG)
- Duke-NUS Medical School (SG)
- National University Health System (SG)
- National Centre for Infectious Diseases (SG)
Publication Details
- Journal
- Singapore Medical Journal
- Published
- 2025-04-09
- DOI
- https://doi.org/10.4103/singaporemedj.smj-2024-089
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40