Personalized Regenerative Rehabilitation of Osteoarthritis Based on Mechanical Loading and Mechanoregulation

Osteoarthritis is one of the most important “civilizational diseases" that significantly restricts quality of life and active life expectancy. The current practice of treating patients with osteoarthritis often consists in replacing damaged natural joints with artificial ones. Even if the replacement procedure is successful, various complications may occur in the post operation period causing health problems in the long term. The purpose of the current research is to develop methods of regenerative rehabilitation of joints on the basis of personalized treatment technologies of osteoarthritis. This goal can be achieved through the development of programmed mechanical loading of joints taking into account modern knowledge about mechanoregulation of cells, as well as applications of tissue-engineered structures using induced pluripotent stem cells. Local regeneration processes can be supported by targeted delivery of microcapsules of multicomponent lubricants, as well as drugs.