Purple-Grain Wheat Regulation of Blood Lipids and Blood Glucose in Diet-Induced Hyperlipidemic Mice and Type 2 Diabetic Mice

<b>Background/Objectives:</b> Disorders of glucose and lipid metabolism can easily lead to metabolic diseases such as hyperlipidemia and diabetes mellitus, with multiple complications. This study evaluated the regulatory effect of purple-grain wheat on glycolipid metabolism. <b>Methods:</b> In this study, we established a hyperlipidemic mouse model by means of a high-fat diet and a type 2 diabetic mouse model using a high-fat and high-sugar diet combined with streptozotocin, and the mice were intervened with 15 g/(kg·d), 7.5 g/(kg·d), and 3.75 g/(kg·d) doses of purple-grain wheat paste (PWP) for 4 and 5 weeks, respectively. <b>Results:</b> The results revealed that PWP reversed the increase in body weight; increased serum high-density lipoprotein cholesterol; and decreased serum total cholesterol, triglycerides, and low-density lipoproteins. In addition, PWP reversed the decrease in body weight and alleviated the sustained increase in blood glucose in type 2 diabetic mice. <b>Conclusions:</b> PWP shows a significant ability to regulate glycolipid levels, which is related to its functional composition and its ability to act as a prebiotic. In conclusion, PWP can be considered a potential functional food for lowering blood glucose and blood lipids.