Effects of Anti-CD20 Antibody Therapy on Immune Cell Dynamics in Relapsing-Remitting Multiple Sclerosis
Our interim data add weight to the argumentation that the exhaustion/activation markers, notably TIGIT, may be relevant to the pathogenesis of MS. In addition, we identify a potentially interesting increase in the expression of CD5+ on B cells. Finally, we identified a population of double-negative T cells (KLRG1+HLADR+, in particular) that is associated with MS activity and decreased with CD20 depletion.
Authors
- Philipp A. Lang (ORCID: https://orcid.org/0000-0001-5341-0407)
- Kristin S. Golombeck
- Melanie Korsen (ORCID: https://orcid.org/0000-0003-2882-002X)
- Margit Weise
- Menekse Öztürk
- Niklas Huntemann (ORCID: https://orcid.org/0000-0003-0015-8484)
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Saskia Räuber (ORCID: https://orcid.org/0000-0001-8901-5572)
- Lars Masanneck (ORCID: https://orcid.org/0000-0003-2496-1415)
- Tobias Ruck (ORCID: https://orcid.org/0000-0001-6332-8650)
- Steffen Pfeuffer (ORCID: https://orcid.org/0000-0001-5171-4845)
- Stefanie Lichtenberg (ORCID: https://orcid.org/0000-0003-4703-2571)
- Saskia Elben (ORCID: https://orcid.org/0000-0002-4214-4550)
- Hans‐Peter Hartung (ORCID: https://orcid.org/0000-0002-0614-6989)
- Alice Willison (ORCID: https://orcid.org/0000-0002-0719-8334)
- Nico Melzer (ORCID: https://orcid.org/0000-0002-2420-701X)
- Marc Pawlitzki (ORCID: https://orcid.org/0000-0003-3080-2277)
- Leoni Rolfes (ORCID: https://orcid.org/0000-0003-4494-951X)
- Stephen L. Hauser
- Ramona Hagler
- Lara-Maria Preuth
Institutions
- The University of Sydney (AU)
- University of California, San Francisco (US)
- Justus-Liebig-Universität Gießen (DE)
- Düsseldorf University Hospital (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Heinrich Heine University Düsseldorf (DE)
- Palacký University Olomouc (CZ)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cells
- Published
- 2025-04-06
- DOI
- https://doi.org/10.3390/cells14070552
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Novartis Pharma