IL-6 trans-signaling mediates cytokine secretion and barrier dysfunction in hantavirus-infected cells and correlates to severity in HFRS
IL-6 trans-signaling is linked to hantavirus pathogenesis. Targeting IL-6 trans-signaling might provide a therapeutic strategy for treatment of severe HFRS and perhaps also HPS.
Authors
- Linda Niemetz
- Julia Wigren-Byström (ORCID: https://orcid.org/0000-0001-9131-5945)
- Wanda Christ (ORCID: https://orcid.org/0000-0003-3886-5248)
- Therese Thunberg
- Jonas Klingström (ORCID: https://orcid.org/0000-0001-9076-1441)
- Clas Ahlm (ORCID: https://orcid.org/0000-0003-2018-8592)
- Kimia T. Maleki (ORCID: https://orcid.org/0000-0001-5382-5477)
Institutions
- Linköping University (SE)
- Karolinska Institutet (SE)
- Umeå University (SE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- PLoS Pathogens
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1371/journal.ppat.1013042
- Citations
- 5
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 6.98
Funders
- Hjärt-Lungfonden
- Vetenskapsrådet
- Umeå Universitet
- Medicinska fakulteten, Umeå Universitet
- Center for Innovative Medicine