Hidden in <scp>CAKUT</scp>: Post‐Transplant Diagnosis of Primary Hyperoxaluria Type 1 and Rescue Management Using Lumasiran

This case underscores the importance of maintaining a high index of suspicion for PH1 in patients with congenital anomalies of the kidney and urinary tract (CAKUT) or unexplained end-stage kidney disease (ESKD) cases, even post-transplantation. It also demonstrates the potential efficacy of lumasiran in managing PH1 post-transplantation when combined with intensive hemodialysis and supportive care. However, more studies with prolonged follow-up periods are necessary to establish the long-term efficacy and safety of lumasiran in the treatment of PH1 without the requirement for liver transplantation.

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Publication Details

Journal
Pediatric Transplantation
Published
2025-04-09
DOI
https://doi.org/10.1111/petr.70079
Citations
1
Primary Topic
Kidney Stones and Urolithiasis Treatments
Type
article
Field-Weighted Citation Impact
1.52
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article

Hidden in CAKUT: Post‐Transplant Diagnosis of Primary Hyperoxaluria Type 1 and Rescue Management Using Lumasiran

Najla Aldaoud, Alanoud Alshami, Ammar Hamed, Ahmed Y. Azzam et al.
1 citations
Pediatric Transplantation
Kidney Stones and Urolithiasis Treatments
1.52
article

Hidden in CAKUT: Post‐Transplant Diagnosis of Primary Hyperoxaluria Type 1 and Rescue Management Using Lumasiran

Najla Aldaoud, Alanoud Alshami, Ammar Hamed, Ahmed Y. Azzam, Hebatallah Bahbah
article en
1 citations

Abstract

This case underscores the importance of maintaining a high index of suspicion for PH1 in patients with congenital anomalies of the kidney and urinary tract (CAKUT) or unexplained end-stage kidney disease (ESKD) cases, even post-transplantation. It also demonstrates the potential efficacy of lumasiran in managing PH1 post-transplantation when combined with intensive hemodialysis and supportive care. However, more studies with prolonged follow-up periods are necessary to establish the long-term efficacy and safety of lumasiran in the treatment of PH1 without the requirement for liver transplantation.

Pediatric TransplantationVol. 29(3)
Jordan University of Science and Technology (JO), King Fahad Specialist Hospital (SA)
Good health and well-being
Openalex Percentile: Top 20%
Kidney Stones and Urolithiasis Treatments
1.52
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