Reconstruction of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveals functional miRNAs and lncRNAs in burns and keloids
All nodes within the sub-ceRNA network exert either a direct or an indirect influence on the pathological processes of burns and post-burn keloids. The current study successfully constructed the ceRNA network in burns and keloids and provided a potentially novel perspective on the DELs-DEMis-DEMs ceRNA network, contributing to the elucidation of the ceRNA regulatory mechanisms in the pathogenesis of burns and keloids. Nevertheless, systematic and rigorous experimental validations are indispensable to confirm our findings.
Authors
- Junbo Zou (ORCID: https://orcid.org/0000-0002-1651-4722)
- Yueru Wang (ORCID: https://orcid.org/0009-0009-1052-8953)
- Zhichao Wang (ORCID: https://orcid.org/0000-0002-4237-5084)
- Jing Liu (ORCID: https://orcid.org/0000-0002-6730-9198)
- He Wang
- Huan Lv (ORCID: https://orcid.org/0009-0005-2626-3938)
- Ziwen Lei
- Fei Luan (ORCID: https://orcid.org/0009-0004-0584-797X)
- Jiaojiao Pan
Institutions
- Heilongjiang Center for Tuberculosis Control and Prevention (CN)
- Shaanxi Institute of International Trade & Commerce (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1371/journal.pone.0320855
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00