Instrument Multiplexing: Amplified Throughput for Measurement of Vitamin B1 in Whole Blood Using Parallel Liquid Chromatography Systems Interfaced to a Single Mass Spectrometer
An accurate, specific, and high-throughput LC-MS/MS method was developed and validated to measure TDP in whole blood. Simple, fast sample preparation was employed for adaptation to a staggered injection, multiple LC-stream platform, which minimized mass spectrometer idle time significantly and improved efficiency.
Authors
- Elizabeth L. Frank
- Preejith Vachali
- Erik Kish‐Trier (ORCID: https://orcid.org/0000-0002-2214-027X)
- Sophie Steckel
Institutions
- University of Utah (US)
- ARUP Institute for Clinical and Experimental Pathology
- ARUP Laboratories (United States) (US)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1093/clinchem/hvaf029
- Citations
- 2
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 2.78