Interleukin (IL)-34 promotes the inflammatory role of IL-1β-producing myeloid cells in pemphigus lesions
IL-1β-producing myeloid cells play a crucial role in the formation of ELS in pemphigus lesions through inflammatory and chemotactic pathways. Keratinocytes contribute to this process by producing IL-34, which fuels local inflammation. These findings offer new insights into pemphigus immunopathogenesis and suggest the IL-34/CSF-1R pathway as a potential therapeutic target.
Authors
- Chuqiao Xu (ORCID: https://orcid.org/0000-0001-7353-7683)
- Chuanxin Huang (ORCID: https://orcid.org/0000-0003-2667-9587)
- Jie Zheng (ORCID: https://orcid.org/0000-0002-7961-6427)
- Haiqin Zhu (ORCID: https://orcid.org/0000-0003-4505-9420)
- Wenzhe Zhao (ORCID: https://orcid.org/0000-0003-4745-5611)
- Meng Pan (ORCID: https://orcid.org/0000-0003-4947-9369)
- Zixuan Huang (ORCID: https://orcid.org/0000-0003-3958-1925)
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
- Institute of Immunology (HR)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1093/bjd/ljaf130
- Citations
- 1
- Primary Topic
- Autoimmune Bullous Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47