Optical coherence tomography in patients with major depressive disorder
ONL thinning in MDD suggests possible neurodegenerative processes that may disturb signal transmission downstream, as indicated by altered ERG responses in MDD. Further research is essential to determine the reversibility of these structural changes following remission. Structural retinal analysis with OCT offers the potential to complement functional ERG examinations and represents a promising approach for developing diagnostic and therapeutic monitoring tools for MDD.
Authors
- Katharina Domschke (ORCID: https://orcid.org/0000-0002-2550-9132)
- Jürgen Kornmeier (ORCID: https://orcid.org/0000-0001-7798-3541)
- Ludger Tebartz van Elst (ORCID: https://orcid.org/0000-0002-2274-5447)
- Sven P. Heinrich (ORCID: https://orcid.org/0000-0003-4906-3937)
- Kimon Runge (ORCID: https://orcid.org/0000-0002-0263-4360)
- Sebastian Küchlin (ORCID: https://orcid.org/0000-0003-0758-5120)
- Simon Maier
- Evelyn B. N. Friedel (ORCID: https://orcid.org/0000-0001-9862-9656)
- Dominique Endres (ORCID: https://orcid.org/0000-0001-7322-1195)
- Kathrin Nickel (ORCID: https://orcid.org/0000-0001-9863-317X)
- Malina Beringer (ORCID: https://orcid.org/0009-0009-3337-2357)
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Institute for Frontier Areas of Psychology and Mental Health (DE)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12888-025-06775-7
- Citations
- 1
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Albert-Ludwigs-Universität Freiburg
- Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg