Genomic and functional analysis of rmp locus variants in Klebsiella pneumoniae
These results provide an overview of the diversity and evolution of a prominent K. pneumoniae virulence factor and support the idea that screening for rmpADC in K. pneumoniae isolates and genomes is valuable to monitor the emergence and spread of hypermucoid K. pneumoniae, including AMR strains.
Authors
- Margaret M. C. Lam (ORCID: https://orcid.org/0000-0001-9590-6849)
- Louise M. Judd (ORCID: https://orcid.org/0000-0003-3613-4839)
- Kimberly A. Walker (ORCID: https://orcid.org/0000-0002-6360-2792)
- Kelly L. Wyres (ORCID: https://orcid.org/0000-0002-4033-6639)
- Virginia L. Miller (ORCID: https://orcid.org/0000-0002-9522-1767)
- Sylvain Brisse (ORCID: https://orcid.org/0000-0002-2516-2108)
- Logan P. Treat (ORCID: https://orcid.org/0009-0008-2877-7432)
- Kathryn E. Holt (ORCID: https://orcid.org/0000-0003-3949-2471)
- Ryan R. Wick (ORCID: https://orcid.org/0000-0001-8349-0778)
- Stephen M. Salisbury (ORCID: https://orcid.org/0009-0008-6278-7837)
Institutions
- University of North Carolina at Chapel Hill (US)
- Burnet Institute (AU)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- London School of Hygiene & Tropical Medicine (GB)
- Monash University (AU)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s13073-025-01461-5
- Citations
- 17
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 10.05
Funders
- Bill and Melinda Gates Foundation
- Medical Research Council
- National Health and Medical Research Council