Effect of aging on resting state functional connectivity between basal forebrain and dentate gyrus in humans

The basal forebrain and dentate gyrus are integral to various cognitive functions. Prior research has identified structural alterations in these regions associated with aging. Nonetheless, the functional interactions between the basal forebrain and dentate gyrus over the lifespan are not well elucidated. In this study, we analyzed resting-state functional magnetic resonance imaging data from a convenience sample of 102 adults aged 56-85 years. Our findings reveal a significant negative correlation between age and the strength of functional connectivity between the basal forebrain and the dentate gyrus across all participants. These results enhance our understanding of the interaction between the basal forebrain and dentate gyrus within the context of aging in the human brain.