Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke
<i>In vivo</i>, imaging showed a higher accumulation of EPC exosomes following LIPFUS without any damage to the underlying brain tissues, increased leakage of albumin, or accumulation of CD45+ cells. Groups of mice (14-16 months old) were treated with Vehicle (PBS), LIPFUS only, EPC-exosomes only, and LIPFUS+EPC-exosomes. LIPFUS + EPC exosomes groups showed a significantly decreased stroke volume on day 7, decreased FluoroJade+ cells, and significantly higher numbers of neovascularization in and around the stroke areas compared to that of other groups.
Authors
- Hasanul Chowdhury
- Ali S. Arbab (ORCID: https://orcid.org/0000-0003-2902-3671)
- Dylan M. Williams (ORCID: https://orcid.org/0000-0002-3825-2487)
- Ahmet Alptekin (ORCID: https://orcid.org/0000-0002-7039-1911)
- Krishnan M. Dhandapani (ORCID: https://orcid.org/0000-0001-7044-1117)
- Mahrima Parvin (ORCID: https://orcid.org/0000-0003-2797-0827)
- Mohammad Badruzzaman Khan (ORCID: https://orcid.org/0000-0001-8231-1256)
- F Selina
- Asamoah Bosomtwi
- Anika Bushra (ORCID: https://orcid.org/0000-0001-5603-075X)
- Santu Ghosh (ORCID: https://orcid.org/0000-0002-9373-9570)
- Joseph A. Frank (ORCID: https://orcid.org/0000-0001-8636-7273)
- Roxan Ara (ORCID: https://orcid.org/0009-0001-0581-640X)
- Joseph F. Kelleher
- Sawaiz Kashif
- Emily Blumling
Institutions
- Augusta University (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fneur.2025.1543133
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- American Heart Association
- Augusta University
- National Institutes of Health