Pediatric densitometry: is the Z score adjustment necessary in all cases?
The high diagnostic discrepancy rate (7%) for LBMN in this unselected pediatric cohort underscores the value of performing HAZ adjustment of Z-scores to improve diagnostic accuracy. This divergence between adjusted and unadjusted Z-scores suggests that all pediatric patients, not only those with short stature or growth retardation, may benefit from densitometric size adjustment. This is especially true in individuals whose stature is at the upper end of the range, where size may obscure a diagnosis of LBMD.
Authors
- Silvia Herrera (ORCID: https://orcid.org/0009-0002-3026-4157)
- Hye Sang Park (ORCID: https://orcid.org/0000-0002-4972-9527)
- Mireia López-Corbeto (ORCID: https://orcid.org/0000-0003-1166-1456)
- Jorge Malouf (ORCID: https://orcid.org/0000-0001-5185-520X)
- Dacia Cerdá (ORCID: https://orcid.org/0000-0002-3701-6124)
- Hèctor Corominas (ORCID: https://orcid.org/0000-0002-7738-6787)
- Gloria Fraga
- Ignasi Gich (ORCID: https://orcid.org/0000-0003-3975-6588)
- Estefanía Quesada‐Masachs (ORCID: https://orcid.org/0000-0001-6033-1176)
- Jordi Casademont (ORCID: https://orcid.org/0000-0002-8100-1827)
- Susana Boronat (ORCID: https://orcid.org/0000-0001-7096-5578)
- Helena Codes-Méndez (ORCID: https://orcid.org/0000-0002-9883-9845)
- Ana Marín (ORCID: https://orcid.org/0000-0003-2873-456X)
- Berta Magallares
- Jocelyn Betancourt
- Montserrat Torrent
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Hospital Universitario Dexeus (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital de Sant Joan Despí Moisès Broggi (ES)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fendo.2025.1587382
- Citations
- 2
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 2.86