Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity
The results indicate that these NPs induce robust humoral and cellular immune responses, potentially offering a promising strategy for effective vaccine development against SARS-CoV-2.
Authors
- Tong Yin (ORCID: https://orcid.org/0000-0002-3399-7092)
- Zhao Yu (ORCID: https://orcid.org/0000-0003-4184-0957)
- Xiaopan Liu
- Yaming Shan (ORCID: https://orcid.org/0000-0001-8373-6088)
- Julia H. Hui
- Yue Liu (ORCID: https://orcid.org/0000-0002-2700-922X)
- Chenxi Li (ORCID: https://orcid.org/0000-0001-9766-5751)
- Qingyu Wang (ORCID: https://orcid.org/0000-0002-6298-5357)
- Yi Pan (ORCID: https://orcid.org/0009-0009-5417-6013)
- Xinglong Qu
- Zirui Wu
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1560330
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Department of Science and Technology of Jilin Province