TRPC3 contributes to cyclophosphamide-induced cystitis progression by enhancing bladder fibrosis through activation of the TGF-β/smad pathway
TRPC3 activation contributes significantly to bladder fibrosis in IC/BPS. Inhibiting TRPC3 ameliorates symptoms by modulating TGF-β/Smad pathway, suggesting it as a promising therapeutic target for managing this challenging condition with limited current treatment options.
Authors
- Ruixiang Luo
- Jialiang Chen (ORCID: https://orcid.org/0000-0001-8586-6839)
- Junlong Huang (ORCID: https://orcid.org/0009-0005-0295-9965)
- Honglu Ding
- Zheng Liu (ORCID: https://orcid.org/0000-0002-4252-4617)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-9209-4934)
- Wenshuang Li (ORCID: https://orcid.org/0000-0001-8012-2339)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fphar.2025.1565156
- Citations
- 1
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province