Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway
DSS alleviates AD symptoms by suppressing neuronal ferroptosis via the AMPK/Sp1/ACSL4 axis, representing a novel lipid metabolism-targeted therapeutic strategy.
Authors
- Chuanguo Liu
- Xin Yu (ORCID: https://orcid.org/0000-0002-2337-748X)
- Yixiao Zhou (ORCID: https://orcid.org/0000-0002-6142-5956)
- Kai Gong (ORCID: https://orcid.org/0000-0002-2903-5341)
- Qingjun Zhu (ORCID: https://orcid.org/0000-0001-6473-2153)
- Kaihui Lu (ORCID: https://orcid.org/0000-0002-7900-0147)
- Jiang Zhu (ORCID: https://orcid.org/0009-0007-0026-3918)
- Shuang Zhou (ORCID: https://orcid.org/0000-0002-2403-7161)
- Xiao Li (ORCID: https://orcid.org/0000-0002-4688-2657)
- Meng-Zhen Xu (ORCID: https://orcid.org/0000-0002-1735-3596)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fphar.2025.1588375
- Citations
- 7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Science and Technology Development Plan of Shandong Province