Brain MRI and regional vulnerabilities to radiation necrosis: investigating the impact of stereotactic radiotherapy in brain metastases treatment
This study underscores the importance of brain region and stem cell niche involvement in the development of radiation necrosis following stereotactic radiotherapy. These findings might have implications for optimizing radiotherapy planning and developing targeted strategies to mitigate the risk of radiation necrosis. Future research should focus on exploring the molecular mechanisms underlying these associations and evaluating potential neuroprotective interventions.
Authors
- Bruno Beomonte Zobel (ORCID: https://orcid.org/0000-0001-9227-5535)
- Ugo Ferrari
- Sara Ramella (ORCID: https://orcid.org/0000-0002-5782-7717)
- F. Giannetti
- E. Herrero Polo
- Carlo Augusto Mallio (ORCID: https://orcid.org/0000-0002-0149-0801)
- Gianfranco Di Gennaro (ORCID: https://orcid.org/0000-0002-7204-4091)
- Edy Ippolito
- Emma Gangemi (ORCID: https://orcid.org/0000-0003-1041-2888)
- Paolo Matteucci (ORCID: https://orcid.org/0000-0002-0594-1577)
- Matteo Pileri (ORCID: https://orcid.org/0000-0003-3516-7727)
- Caterina Bernetti (ORCID: https://orcid.org/0000-0002-7377-6067)
Institutions
- Università Campus Bio-Medico (IT)
- Campus Bio Medico University Hospital (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Radiology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fradi.2025.1554017
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52