Uric acid reduces the expression of aquaporins in renal collecting ducts to increase urine output in hyperuricemia
Our findings demonstrate that UA reduces the expression of AQP2, AQP3 and AQP4 in an NFκB-dependent manner, which contributes to the polyuria phenotype in the subjects with HUA.
Authors
- Hu Xu (ORCID: https://orcid.org/0000-0003-1198-0932)
- Youfei Guan (ORCID: https://orcid.org/0000-0002-5231-0209)
- Rongfang Qiao (ORCID: https://orcid.org/0009-0003-9214-3497)
- Guoying Sun (ORCID: https://orcid.org/0000-0003-2407-0508)
- Wenjuan Hu (ORCID: https://orcid.org/0000-0002-6208-7258)
- Zhi‐Lin Luan (ORCID: https://orcid.org/0000-0003-0774-4718)
- Yitong Hu (ORCID: https://orcid.org/0009-0008-1697-1465)
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-4060-2423)
- Bing Wang (ORCID: https://orcid.org/0000-0003-0810-0789)
- Xiaohui Cui
- Huiwen Ren (ORCID: https://orcid.org/0000-0002-6649-9284)
Institutions
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fphys.2025.1504328
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.43