Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis
The interaction of inhalation-induced airway inflammation and autoimmune arthritis results in lung disease associated with uniquely activated infiltrating inflammatory interstitial macrophages. Moreover, depletion of circulating monocytes attenuated lung disease. Whereas the induced interstitial macrophage immunophenotype is more aligned to CIA than endotoxin exposure, co-exposure modeling renders unique features that potentially inform the pathogenesis and treatment of RA-ILD.
Authors
- Todd A. Wyatt (ORCID: https://orcid.org/0000-0002-9273-6730)
- Jill A. Poole (ORCID: https://orcid.org/0000-0002-6236-2563)
- Geoffrey M. Thiele (ORCID: https://orcid.org/0000-0001-5688-8596)
- Aaron Schwab (ORCID: https://orcid.org/0000-0003-1142-7790)
- Ted R. Mikuls (ORCID: https://orcid.org/0000-0002-0897-2272)
- Bryant R. England (ORCID: https://orcid.org/0000-0002-9649-3588)
- Michael J. Duryee (ORCID: https://orcid.org/0000-0001-9104-2238)
- Oliver Schanze
- Amy Nelson
- Angela Gleason
Institutions
- Nebraska Medical Center (US)
- VA Nebraska Western Iowa Health Care System (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1557583
- Citations
- 2
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- U.S. Department of Defense