Association of C1QTNF6 gene polymorphism with risk and clinical features of type 1 diabetes in Chinese: implications for ZnT8A and beta-cell function
The polymorphism in <i>C1QTNF6</i> was independently associated with T1D risk in Chinese and broadly modified clinical features of the disease. This loci might be utilized to construct genetic risk model in combination with the well-known <i>DR-DQ</i> region for future screening of genetically T1D prone individuals among Chinese.
Authors
- Zhiguo Xie (ORCID: https://orcid.org/0000-0001-5037-3807)
- Gan Huang (ORCID: https://orcid.org/0000-0002-7361-6231)
- Zhiguang Zhou (ORCID: https://orcid.org/0000-0002-4451-4906)
- Xia Li (ORCID: https://orcid.org/0000-0002-0194-0307)
- Ying Xia (ORCID: https://orcid.org/0000-0001-5869-4103)
- Jingyi Hu (ORCID: https://orcid.org/0000-0001-7726-6753)
- J T Liu
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1551552
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Central South University
- Fundamental Research Funds for the Central Universities