Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain
Although TDPs and tonic stimulation comparably mitigated allodynia, TDPs exhibited slower rate of wash-out, suggesting longer-lasting analgesic effects and potentially different mechanisms of action.
Authors
- Ki-Soo Jeong (ORCID: https://orcid.org/0000-0003-1705-8623)
- Victoria Rogness (ORCID: https://orcid.org/0000-0002-6185-0776)
- Muhammad Muzzammil Edhi (ORCID: https://orcid.org/0000-0003-4718-4372)
- Rosana Esteller (ORCID: https://orcid.org/0000-0003-3030-610X)
- Changfang Zhu
- Carl Y. Saab (ORCID: https://orcid.org/0000-0003-4665-9946)
Institutions
- Brown University (US)
- Boston Scientific (United States) (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fpain.2025.1541078
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00