Proteomic analysis of infiltrating neutrophils from rheumatoid arthritis synovial fluid and their contribution to protein carbamylation
Synovial neutrophils were found to be activated and increased releasing protein cargo, including MPO and ROS, into the synovial fluid. Presence of many carbamylated proteins in RA-SF and an increased MPO activity showed a strong correlation to the degree of protein carbamylation, suggesting neutrophil-derived MPO in promoting generation of aberrantly carbamylated proteins.
Authors
- Rikard Holmdahl (ORCID: https://orcid.org/0000-0002-4969-2576)
- Hui Qiu (ORCID: https://orcid.org/0000-0002-8742-0803)
- Kutty Selva Nandakumar (ORCID: https://orcid.org/0000-0001-7790-8197)
- Weimin Qiu
- Xueting Chen (ORCID: https://orcid.org/0000-0002-5314-0221)
- Jian Wan (ORCID: https://orcid.org/0000-0001-9882-3029)
- Xiong Li (ORCID: https://orcid.org/0000-0001-9614-7194)
- Pan Wang (ORCID: https://orcid.org/0000-0001-6034-4639)
- Rong Du (ORCID: https://orcid.org/0009-0004-9737-9359)
- Hui Geng (ORCID: https://orcid.org/0000-0002-8170-7344)
- Lu Chen (ORCID: https://orcid.org/0000-0003-0120-362X)
Institutions
- Union Hospital (HK)
- Karolinska Institutet (SE)
- Wuhan University (CN)
- Central China Normal University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Huazhong University of Science and Technology (CN)
- Halmstad University (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1563426
- Citations
- 4
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Vetenskapsrådet
- Central China Normal University