Infection of a β-galactosidase-deficient mouse strain with Theiler’s murine encephalomyelitis virus reveals limited immunological dysregulations in this lysosomal storage disease
These results suggest that already in the early stage of disease (before clinical onset) G<sub>M1</sub> gangliosidosis causes an impaired T cell response and microglial hyperreactivity.
Authors
- Tim Ebbecke
- Rouven Wannemacher (ORCID: https://orcid.org/0000-0002-7901-7141)
- Felix Stegmann
- Sayali Kalidas Kohale
- Ingo Gerhauser (ORCID: https://orcid.org/0000-0002-7973-7405)
- Bernd Lepenies (ORCID: https://orcid.org/0000-0001-9033-5522)
- Wolfgang Baumgärtner (ORCID: https://orcid.org/0000-0001-8151-5644)
- Deborah Eikelberg
- Melanie Bühler
- Thanaporn Asawapattanakul (ORCID: https://orcid.org/0000-0002-7179-0340)
- Marie-Kristin Raulf (ORCID: https://orcid.org/0000-0001-8967-6741)
- Dandan Li (ORCID: https://orcid.org/0000-0002-3527-3522)
Institutions
- University of Veterinary Medicine Hannover, Foundation (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1467207
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00