Therapeutic effects and mechanisms of Xinmaitong formula for type 2 diabetes mellitus via GLP-1R signaling
XMT exerts hypoglycemic effects by upregulating GLP-1R gene expression, enhancing GLP-1R protein synthesis, and subsequently promoting cAMP release. This process activates Ca<sup>2+</sup> influx in pancreatic β-cells, triggering insulin exocytosis from islet cells.
Authors
- Kang Yang (ORCID: https://orcid.org/0000-0002-7568-1117)
- Jian Gao
- Fen Tian (ORCID: https://orcid.org/0000-0002-7009-1927)
- Yang Pan (ORCID: https://orcid.org/0009-0004-4610-7230)
- Yanmei Li (ORCID: https://orcid.org/0009-0001-1232-7954)
- Jingrui Song
- Yubing Huang
- Weidong Pu
Institutions
- Guiyang Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fphar.2025.1575450
- Citations
- 1
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China