Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited Nicotiana benthamiana
The ability of hPBMCs-engrafted NSG mice to mount specific humoral immune responses after immunization with viral antigens supports this animal model as a promising tool for pre-clinical evaluation of human vaccine antigens.
Authors
- Inger Heldal
- Adrian Onu (ORCID: https://orcid.org/0000-0001-8724-9754)
- Hege Steen
- Ana‐Maria Pantazica (ORCID: https://orcid.org/0000-0001-7958-1474)
- Jihong Liu Clarke (ORCID: https://orcid.org/0000-0002-4924-0406)
- Norica Branza‐Nichita (ORCID: https://orcid.org/0000-0001-7896-7930)
- Sissel Haugslien
- André van Eerde
- Crina Stăvaru (ORCID: https://orcid.org/0000-0001-9311-4418)
- Cătălin Ţucureanu (ORCID: https://orcid.org/0000-0001-5775-5939)
- Vlad Tofan (ORCID: https://orcid.org/0000-0003-4052-2383)
- Irina Ionescu (ORCID: https://orcid.org/0000-0001-8848-7252)
- Iuliana Caraș (ORCID: https://orcid.org/0000-0003-1018-6112)
- Adriana Costache (ORCID: https://orcid.org/0000-0002-8504-0196)
- Raluca-Elena Chelmuş
- Hang Su (ORCID: https://orcid.org/0000-0003-0571-0864)
Institutions
- Norwegian Institute of Bioeconomy Research (NO)
- Institute of Biochemistry (RO)
- Romanian Academy (RO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1479689
- Citations
- 1
- Primary Topic
- Transgenic Plants and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- Norges Forskningsråd
- Academia Româna