Efficient stage-wise allocation ratios in multi-arm multi-stage designs
Our findings highlight the importance of considering stage-wise allocation ratios to align with the specific objectives of a trial. Stage-wise allocation ratios can enhance power and efficiency in MAMS trials, facilitating better decision-making and minimising resource use.
Authors
- James M. S. Wason (ORCID: https://orcid.org/0000-0002-4691-126X)
- Ruqayya Azher
- Michael J. Grayling (ORCID: https://orcid.org/0000-0002-0680-6668)
Institutions
- Janssen (United Kingdom) (GB)
- Decision Sciences (United States) (US)
- Newcastle University (GB)
Publication Details
- Journal
- Contemporary Clinical Trials
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.cct.2025.107908
- Primary Topic
- Optimal Experimental Design Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00