Personalized drug screening of patient-derived tumor-like cell clusters based on specimens obtained from percutaneous transthoracic needle biopsy in patients with lung malignancy: a real-world study
PTC culture based on PTNB specimens could be established in 82.4% of LM patients, with a high accuracy in predicting clinical outcomes. Excessive necrosis in the tumor may predict the failure of PTC culture. Image-guided PTNB targeting enhanced or fluorodeoxyglucose avid regions on images might contribute to improving the success rate of PTC culture.
Authors
- Zheng Wang (ORCID: https://orcid.org/0000-0001-6504-888X)
- Sheng Xu (ORCID: https://orcid.org/0000-0003-0757-8289)
- Xiaoguang Li (ORCID: https://orcid.org/0000-0003-4480-3676)
- Jianzhong Xi (ORCID: https://orcid.org/0000-0003-3015-8418)
- Yidan Ma
- Shih Min Yin
- Zhi‐Xin Bie (ORCID: https://orcid.org/0000-0003-3365-0694)
- Yuanming Li (ORCID: https://orcid.org/0009-0000-9454-1614)
- Jing Qi
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12885-025-14069-0
- Citations
- 2
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04