SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice
The SGLT2 inhibitor ERTU corrected the expression of myocardial gene programs for oxidative phosphorylation and fatty acid metabolism, and was associated with increased production of ATP, decreased release of mitochondrial ROS, and amelioration of the consequences of mitochondrial dysfunction on myocardial structure and function.
Authors
- Tomáš Baka (ORCID: https://orcid.org/0000-0003-4752-9828)
- Adam C. Gower (ORCID: https://orcid.org/0000-0002-6122-7511)
- Dominique Croteau (ORCID: https://orcid.org/0000-0001-9274-5314)
- Wilson S. Colucci (ORCID: https://orcid.org/0000-0002-0576-9420)
- Jordan M. Chambers (ORCID: https://orcid.org/0000-0002-4285-7454)
- David R. Pimentel
- Ivan Luptak (ORCID: https://orcid.org/0000-0001-7498-7694)
- Fuzhong Qin (ORCID: https://orcid.org/0000-0002-9534-3617)
- Marcello Panagia
Institutions
- Boston University (US)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100296
- Citations
- 2
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.59