Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy
Our results outline successful PDCS measurements with large SPAD arrays to enable detect CBF in human adults. The ongoing development of SPAD camera technology is expected to result in larger and faster detectors in the future. In combination with new data processing techniques, tailored for the sparse signal of binary photon detection events in SPADs, this could lead to even greater SNR increase and ultimately greater depth sensitivity of PDCS.
Authors
- Scott A. Huettel (ORCID: https://orcid.org/0000-0002-5092-4936)
- Kanghyun Kim (ORCID: https://orcid.org/0000-0002-4557-9525)
- Paul McKee (ORCID: https://orcid.org/0000-0002-8090-9374)
- Lucas Kreiß (ORCID: https://orcid.org/0000-0002-7749-0015)
- Arin Can Ülkü (ORCID: https://orcid.org/0000-0002-6719-6189)
- Edoardo Charbon (ORCID: https://orcid.org/0000-0002-0620-3365)
- Clare Cook (ORCID: https://orcid.org/0000-0001-5063-6013)
- Melissa M. Wu (ORCID: https://orcid.org/0000-0001-6083-2464)
- Mark Harfouche (ORCID: https://orcid.org/0000-0002-4657-4603)
- Claudio Bruschini (ORCID: https://orcid.org/0000-0002-6636-6596)
- Shiqi Xu (ORCID: https://orcid.org/0000-0002-8450-9001)
- Kyung Chul Lee (ORCID: https://orcid.org/0000-0003-4014-2161)
- Kyle R. Cowdrick (ORCID: https://orcid.org/0000-0003-2236-6137)
- Seung Ah Lee (ORCID: https://orcid.org/0000-0001-5173-1565)
- Roarke Horstmeyer (ORCID: https://orcid.org/0000-0002-2480-9141)
- Erin M. Buckley (ORCID: https://orcid.org/0000-0003-1068-8411)
- Derrick Dwamena
- Wenhui Liu (ORCID: https://orcid.org/0000-0003-1837-9031)
- Xi Yang (ORCID: https://orcid.org/0009-0007-4874-7831)
- Michael Wayne
Institutions
- Georgia Institute of Technology (US)
- Seoul National University (KR)
- Duke University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Tsinghua University (CN)
Publication Details
- Journal
- Neurophotonics
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1117/1.nph.12.2.025007
- Citations
- 7
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 11.44
Funders
- National Science Foundation
- Meta
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Air Force Office of Scientific Research