A single-cell atlas of bladder cancer unveils dynamic cellular composition and endothelial functional shifts during progression
This study reveals stage-specific endothelial cell phenotypes and signaling networks in BC. The identification of an MIBC-specific ADAM10<sup>+</sup> endothelial subset underscores its potential role in driving tumor progression and highlights opportunities for stage-adapted vascular-targeted therapies. These findings advance our understanding of BC pathogenesis and provide the foundation for novel therapeutic strategies.
Authors
- Wanhai Xu (ORCID: https://orcid.org/0000-0003-3442-7988)
- Guoxi Xie (ORCID: https://orcid.org/0000-0002-4842-7252)
- Qing Shi
- Xiaowei Hu (ORCID: https://orcid.org/0000-0002-5708-7018)
- Yaowei Li (ORCID: https://orcid.org/0000-0003-0725-6108)
- Hongjian Song (ORCID: https://orcid.org/0000-0001-7105-1196)
- Zhihao Yin (ORCID: https://orcid.org/0000-0001-6456-3994)
- Zhichao Tong (ORCID: https://orcid.org/0000-0002-2044-5037)
- Ziyi Liu (ORCID: https://orcid.org/0000-0002-2460-6782)
- Ziqi Wang (ORCID: https://orcid.org/0009-0007-6701-5177)
- Zongzheng Yang
- Haonan Li (ORCID: https://orcid.org/0000-0002-0188-646X)
- Yubo Zhao
Institutions
- Harbin Engineering University (CN)
- Harbin Medical University (CN)
- Beijing Graphene Institute (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Botswana Geoscience Institute (BW)
- Second Affiliated Hospital of Harbin Medical University (CN)
- BGI Research (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1007/s12672-025-02297-6
- Citations
- 4
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Heilongjiang Provincial Department of Human Resources and Social Security