Exploring Ferroptosis and Epigenetic Regulation in Gynecological Cancers: Implications for Treatment Strategies

Gynecological malignancies, particularly cervical, ovarian, and endometrial cancers, provide considerable worldwide health challenges due to the increasing incidence of new cases and mortality. Iron-dependent lipid peroxidation, a regulated process of cell death, has emerged as a highly promising focus for cancer clinical treatment. This article presents a thorough analysis of the many processes involved in ferroptosis, focusing specifically on the influence of epigenetic control, which includes histone modification, DNA methylation, non-coding RNAs (ncRNAs), and RNA modifications such as N6-methylcytosine (m6C). Recent findings clarify the complex interactions between epigenetic variables and the expression of genes associated with ferroptosis, which in turn affect the survival, proliferation, and response to treatment of gynecological cancers. Ferroptosis is strongly influenced by epigenetic control, which may lead to better management of gynecological malignancies. More effective treatments for endometrial, ovarian, and cervical malignancies may result from focusing on processes including histone modification, DNA methylation, and non-coding RNAs. Applying these discoveries to improve clinical outcomes and lower mortality should be the main goal of future initiatives.