Ovarian Metastatic Recurrence of Cervical Squamous Cell Carcinoma: A Case Report

Ovarian metastases from squamous cell carcinoma of the uterine cervix are extremely rare. We present the case of a 57-year-old patient who was followed for stage IVA cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO), initially treated with concurrent chemoradiation. Two years after complete remission, she developed bilateral ovarian metastases, which were incidentally discovered and confirmed by histopathological and immunohistochemical analysis. This case represents the first description of ovarian metastases following irradiation of a locally advanced cervical cancer. The occurrence of ovarian metastases in this context, where the ovaries had been irradiated, raises questions about tumor biology and treatment resistance.