Cytoplasmic <scp>HuR</scp> Expression Enhances Chemoresistance in Pleural Mesothelioma Through Increased Expression of <scp>CALB2</scp>, Promotion of the <scp>E2F</scp> Pathway, and Suppression of the p53 Pathway
Cytoplasmic HuR expression increases the chemoresistance and postoperative recurrence risk of pleural mesothelioma, making it a potential biomarker for predicting therapeutic prognosis. However, the mechanism of HuR transfer to the cytoplasm remains unclear for therapeutic application.
Authors
- Yoshinori Taniguchi (ORCID: https://orcid.org/0000-0002-8621-7790)
- Yuko Kinowaki (ORCID: https://orcid.org/0000-0001-8907-2569)
- Keisuke Sugita (ORCID: https://orcid.org/0000-0002-7978-210X)
- Morito Kurata (ORCID: https://orcid.org/0000-0002-1242-6709)
- Susumu Kirimura (ORCID: https://orcid.org/0009-0009-8449-2068)
- Kenichi Okubo (ORCID: https://orcid.org/0000-0003-1092-7814)
- Hironori Ishibashi (ORCID: https://orcid.org/0000-0002-0535-3791)
Institutions
- Tokyo Medical and Dental University (JP)
- The Cancer Institute Hospital (JP)
- Japanese Foundation For Cancer Research (JP)
- Institute of Science Tokyo (JP)
Publication Details
- Journal
- Thoracic Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/1759-7714.70062
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tokyo Medical and Dental University
- Japan Society for the Promotion of Science