Systemic Inflammatory Factors and Neuropsychiatric Disorders: A Bidirectional Mendelian Randomization Study
The results revealed that 14 distinct systemic inflammatory modulators are potentially causally linked to the risk of developing various neuropsychiatric disorders. Specifically, five were associated with AD, eight with ANX, six with DEP, and one with UE. However, the causal associations involving systemic inflammatory markers with PD and MS require further investigation, particularly with the identification of additional significant genetic variants. Furthermore, the concentration levels of 33 systemic inflammatory factors could be modulated by the occurrence of neuropsychiatric conditions, indicated by this study. These include five affected by AD, eight by PD, six by MS, 12 by ANX, five by DEP, and five by UE.
Authors
- Jingtian Wang (ORCID: https://orcid.org/0000-0003-3665-6573)
- Ziji Cheng
- Yanjun Du (ORCID: https://orcid.org/0000-0002-0762-9077)
- Qian Yang (ORCID: https://orcid.org/0000-0002-8797-1824)
- Xiaoming Zhang (ORCID: https://orcid.org/0000-0001-9764-8986)
- Wenyu Liu (ORCID: https://orcid.org/0000-0002-4582-7488)
- Tuo Zhang (ORCID: https://orcid.org/0000-0001-5396-918X)
- Min Wang (ORCID: https://orcid.org/0000-0002-5624-6363)
- Jie Song (ORCID: https://orcid.org/0000-0002-3267-8348)
- Zixuan Xu (ORCID: https://orcid.org/0000-0001-6123-1425)
- Xingyang Sun
- Wang Hq (ORCID: https://orcid.org/0000-0001-7051-2763)
Institutions
- Hubei University of Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/brb3.70478
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Science and Technology Department of Hubei Province