Selective Deletion of HLA-B, and -C Class I Genes Promotes Immunocompatibility of Humanized Skin Graft Model
This genetic engineering approach, repeated without modification for the five HLA-A class I most common alleles known to be associated with HLA-B7 and -C7 in the same haplotype, would cover 83.4% of the world population. Our findings offer a scalable HLA-compatible skin graft model, potentially improving practices in burn units worldwide.
Authors
- Carmen Mir
- Daniel López (ORCID: https://orcid.org/0000-0003-0268-5878)
- Laura Cobos-Figueroa (ORCID: https://orcid.org/0000-0002-0091-8693)
- Elena Lorente (ORCID: https://orcid.org/0000-0002-2246-6851)
- C. Molpeceres (ORCID: https://orcid.org/0000-0002-6236-8359)
- S. Lauzurica (ORCID: https://orcid.org/0000-0003-4398-6474)
- Laura Notario (ORCID: https://orcid.org/0000-0001-8940-1916)
- Pilar Lauzurica (ORCID: https://orcid.org/0000-0001-6579-1948)
Institutions
- Instituto de Salud Carlos III (ES)
- Centro Nacional de Microbiologia (ES)
- Universidad Politécnica de Madrid (ES)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/itt.s506352
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comunidad de Madrid
- Ministerio de Ciencia, Innovación y Universidades
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación