Advances in the Preparation, Evaluation, and Genetic Research of Animal Models for Developmental Dysplasia of the Hip

本文综述了先天性髋关节发育不良(Developmental Dysplasia of the Hip, DDH)动物模型的制备、评估方法及遗传学研究的最新进展。通过分析手术诱导、自然发生和遗传工程三种模型，深入探讨了DDH的病理生理机制。研究强调了模型评估中整体性能、区分度、校准和重分类能力等关键指标的重要性，并讨论了遗传学研究在识别DDH易感基因和遗传标记方面的成果。本文为DDH的预防、早期诊断和治疗提供了科学基础，并指出了未来研究的方向，有望改善患者预后。This article reviews the latest advancements in the preparation and evaluation methods of animal models for Developmental Dysplasia of the Hip (DDH), as well as progress in genetic research. By analyzing three types of models—surgically induced, naturally occurring, and genetically engineered—the article delves into the pathophysiological mechanisms of DDH. The study emphasizes the importance of key indicators in model evaluation, such as overall performance, discrimination, calibration, and reclassification ability, and discusses the achievements of genetic research in identifying susceptibility genes and genetic markers for DDH. The article provides a scientific basis for the prevention, early diagnosis, and treatment of DDH, and points out the direction for future research, which is expected to improve patient prognosis.