MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer
The current study showed that MDM1 expression influences the sensitivity of CRC cells to chemoradiation by influencing p53 and apoptosis pathways, which is the basis for the underlying molecular mechanism, and serves as a possible predictive marker for chemoradiotherapy prognosis.
Authors
- Ruoqing Yan
- Ying Huang (ORCID: https://orcid.org/0000-0003-1005-7564)
- H Chen (ORCID: https://orcid.org/0009-0001-5187-8644)
- Shaosen Zhang (ORCID: https://orcid.org/0000-0003-0010-1445)
- Ningxin Ren
- Ye‐Xiong Li (ORCID: https://orcid.org/0000-0003-0985-235X)
- Wen Tan (ORCID: https://orcid.org/0000-0002-7231-7838)
- Shuangmei Zou (ORCID: https://orcid.org/0000-0001-8539-6291)
- Jing Jin (ORCID: https://orcid.org/0000-0001-9726-7323)
- Dongxin Lin (ORCID: https://orcid.org/0000-0002-8723-8868)
- Mengjie Li (ORCID: https://orcid.org/0000-0003-2544-2115)
- Linlin Zheng (ORCID: https://orcid.org/0000-0003-2798-4727)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Respiratory Disease (CN)
- State Key Laboratory of Oncology in South China
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2025-04-08
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2024.0540
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Key Laboratory of Molecular Oncology