The Potential of Ruthenium(II) Tris‐Bidentate Complexes as Multifunctional Photo‐Initiators
Abstract An optically active antibacterial ruthenium(II) phenanthroline complex (tris(3,4,7,8‐tetramethyl‐1,10‐phenanthroline) ruthenium(II) dichloride), is investigated for its potential as a multifunctional photo‐initiator. Antibacterial and cytotoxic studies indicated that the complex is biologically active, and viable below <0.5 m m . The complex is shown to photo‐polymerize gelatin using visible light in a similar manner to tris(2,2′‐bipyridyl)ruthenium(II) dichloride and is demonstrated to retain antibacterial activity post‐fabrication of a gelatin hydrogel. Incorporation of the photo‐initiator into the interstitial fluid of a hybrid gelatin granular scaffold generated a multifunctional scaffold that retained cell viability and exhibited injectable properties.
Authors
- Habib Joukhdar (ORCID: https://orcid.org/0000-0001-5091-5047)
- Khoon S. Lim (ORCID: https://orcid.org/0000-0002-2486-196X)
- James D. Crowley (ORCID: https://orcid.org/0000-0002-3364-2267)
- Vinh Khanh Doan (ORCID: https://orcid.org/0000-0002-2032-0453)
- C. F. Xu (ORCID: https://orcid.org/0000-0001-8831-3607)
- Quinn van Hilst (ORCID: https://orcid.org/0009-0007-4895-8452)
- Bram G. Soliman (ORCID: https://orcid.org/0009-0003-7709-165X)
- Jelena Rnjak‐Kovacina (ORCID: https://orcid.org/0000-0001-6121-4676)
- Kieran Lau (ORCID: https://orcid.org/0000-0003-4756-2644)
- Tim B. F. Woodfield (ORCID: https://orcid.org/0000-0002-5428-7575)
- Siyuan Liu (ORCID: https://orcid.org/0000-0002-8292-7090)
- Yiwei Li (ORCID: https://orcid.org/0009-0003-5086-9433)
- Yi Wang (ORCID: https://orcid.org/0000-0002-4832-443X)
- Chien‐Ming Hsu
- Qishu He
Institutions
- The University of Sydney (AU)
- Sydney Dental Hospital (AU)
- UNSW Sydney (AU)
- University of Otago (NZ)
- MacDiarmid Institute for Advanced Materials and Nanotechnology (NZ)
Publication Details
- Journal
- Macromolecular Materials and Engineering
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1002/mame.202400458
- Citations
- 5
- Primary Topic
- Photochromic and Fluorescence Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Australian Government
- University of New South Wales
- University of Sydney
- NSW Ministry of Health
- Australian Research Council