S100A8/A9 high-expression macrophages mediate renal tubular epithelial cell damage in acute kidney injury following acute type A aortic dissection surgery
These findings suggested that S100A8/A9 were promising predictive biomarkers for AKI after surgery for ATAAD. S100A8/A9 were upregulated and primarily localized in renal macrophages, where they promoted the transformation of macrophages into the M1 phenotype. S100A8/A9 overexpressed macrophages activated the TNF signaling pathway through secretion and direct interaction with renal tubular epithelial cells, highlighting the critical role of TNF signaling in AKI after ATAAD surgery.
Authors
- Xiujuan Cai
- Dongjin Wang (ORCID: https://orcid.org/0000-0001-6499-1972)
- Jie Yang (ORCID: https://orcid.org/0000-0003-1789-690X)
- Ronghuang Yu
- Zhigang Wang (ORCID: https://orcid.org/0000-0003-3931-6064)
- Xin Li (ORCID: https://orcid.org/0000-0002-6352-6523)
- Jian Shi (ORCID: https://orcid.org/0000-0003-4115-8819)
- Lu Tang (ORCID: https://orcid.org/0009-0001-7807-614X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fmolb.2025.1530741
- Citations
- 2
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 3.04