Maternal exposure to high-fat diet induces long-term mitochondrial alterations in the offspring heart
Maternal exposure to HFD enhanced mitochondrial damage and impaired fission and clearance in offspring hearts at adulthood. These alterations were associated with altered expression of proteins involved in the mitochondrial electron transport chain coupled with a propensity for increased fatty acid accumulation and elevated proinflammatory markers.
Authors
- François Cachat (ORCID: https://orcid.org/0000-0003-1173-2488)
- Claire Mauduit (ORCID: https://orcid.org/0000-0001-7835-2610)
- Hassib Chehade (ORCID: https://orcid.org/0000-0001-5019-2547)
- Mariapia Chindamo
- Mohamed Benahmed (ORCID: https://orcid.org/0000-0002-7105-0596)
- Umberto Siméoni (ORCID: https://orcid.org/0000-0003-0730-9337)
- Bénazir Siddeek (ORCID: https://orcid.org/0000-0003-2764-6656)
- Anthony Sordet
- Gaël Humbert-Droz
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire Vaudois (CH)
- Centre Méditerranéen de Médecine Moléculaire (FR)
Publication Details
- Journal
- Nutrition
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.nut.2025.112796
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00