Breath of change: Evaluating the healthcare impact of the race-neutral Global Lung Initiative (GLI) 2022 on adults with cystic fibrosis

This study evaluates the clinical impact of transitioning from the GLI 2012 to the race-neutral GLI 2022 spirometry equations in people with cystic fibrosis (pwCF). Spirometry data from a large adult CF centre showed an increase in average ppFEV₁ (71.1 %-75 %, p < 0.01), with White patients showing the greatest change (4.56 %). Fewer patients met lung transplantation thresholds, and 1.7 % became newly eligible for clinical trials, while 7 % became ineligible. These findings suggest the need for further research on the long-term implications of GLI 2022 across respiratory conditions.